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Lung cancer: Immunotherapy

Journal articles and book chapters

04-10-2019 | Non-small-cell lung cancer | Video | Article

Expert comment: The CheckMate 227 study

Sanjay Popat brings context to the CheckMate 227 data in light of the currently available options for patients with treatment-naïve, advanced non-small-cell lung cancer, highlighting the key aspects physicians need to bear in mind when considering nivolumab­ plus ipilimumab for their patients (2:20).

02-10-2019 | Non-small-cell lung cancer | Video | Article

Expert highlights: Lung and thoracic cancers at ESMO 2019

Ross Camidge comments on the advanced non-small-cell lung cancer research that caught his attention at the ESMO Congress 2019, including the FLAURA and CheckMate 227 overall survival data, and updates on brigatinib and lorlatinib (3:01).

01-10-2019 | Non-small-cell lung cancer | Video | Article

Researcher comment: Take-home messages from the CheckMate 227 trial

Solange Peters discusses the implications of the CheckMate 227 findings for the front-line treatment of advanced non-small-cell lung cancer and outlines the key next steps (3:45).

13-09-2019 | Small-cell lung cancer | Video | Article

Expert comment: CASPIAN trial of durvalumab in SCLC

WATCH | Raffaele Califano comments on the CASPIAN trial of front-line durvalumab plus chemotherapy in extensive-stage small-cell lung cancer, and puts the findings in context of the IMpower133 study of atezolizumab in the same setting (3:30).

09-09-2019 | Non-small-cell lung cancer | Video | Article

Researcher comment: TMB not prognostic for KEYNOTE-189 participant outcomes

WATCH | Marina Garassino reports the KEYNOTE-189 tumor mutational burden analysis and what the findings mean for this biomarker (4:03).

09-09-2019 | Non-small-cell lung cancer | Video | Article

Researcher comment: CheckMate 817 trial of nivolumab–ipilimumab

WATCH | Is first-line nivolumab–ipilimumab a feasible option for certain subgroups of advanced non-small-cell lung cancer patients, such as those with poor functional status? Fabrice Barlesi discusses the CheckMate 817 trial (3:32).

08-09-2019 | Non-small-cell lung cancer | Video | Article

Researcher comment: TMB does not predict NSCLC pembrolizumab–chemotherapy response

WATCH | Corey Langer describes the findings from the KEYNOTE-021 exploratory analysis of the relationship between response to pembrolizumab plus chemotherapy and tumor mutational burden in metastatic non-small-cell lung cancer patients (7:35).

08-09-2019 | Lung cancer | Video | Article

Expert highlights from WCLC 2019

WATCH | Advisory Board member Ross Camidge shares his top picks of the presentations at the 2019 World Conference on Lung Cancer, including the CASPIAN trial and the updated AMG 510 data (1:51).

17-06-2019 | Small-cell lung cancer | Article

Immune Checkpoint Inhibitors in Small Cell Lung Cancer: A Partially Realized Potential

Armstrong SA & Liu SV. Adv Ther 2019. doi:10.1007/s12325-019-01008-2

04-06-2019 | Non-small-cell lung cancer | Video | Article

Expert comment: 5-year update of KEYNOTE-001

ASCO expert David Graham tells us just why he thinks the 5-year survival data from the advanced non-small-cell lung cancer patients enrolled in the phase Ib KEYNOTE-001 trial are so remarkable (1:26).

03-06-2019 | Non-small-cell lung cancer | Video | Article

Researcher comment: 5-year KEYNOTE-001 results show long-lasting survival for some advanced NSCLC patients

Edward Garon presents the 5-year follow-up results of the advanced non-small-cell lung cancer cohort of the phase I KEYNOTE-001 trial of pembrolizumab monotherapy (4:12).

01-04-2019 | Malignant pleural disease | Video | Article

Researcher comment: CAR T-cell therapy for malignant pleural disease

Prasad Adusumilli outlines the key results of their phase I trial showing promising safety and efficacy of a mesothelin-targeted chimeric antigen receptor T-cell therapy in patients with malignant pleural disease, and also discusses the next steps (4:09).

04-02-2019 | Non-small-cell lung cancer | Article

Comparing and contrasting predictive biomarkers for immunotherapy and targeted therapy of NSCLC

Camidge DR et al. Nat Rev Clin Oncol 2019; 16(6): 341-355. doi:10.1038/s41571-019-0173-9.

12-12-2018 | Immunotherapy | Feature | Article

Hyperprogression as a response to immunotherapy: ‘A serious downside’

In light of recent reports of hyperprogression in response to treatment with cancer immunotherapy, medwireNews spoke to medical oncologist Razelle Kurzrock (University of California, San Diego, La Jolla, USA) about the phenomenon, the implications for therapy, and future directions for research.

05-06-2018 | Radiotherapy | Article

Safety of combining radiotherapy with immune-checkpoint inhibition

Hwang WL et al. Nat Rev Clin Oncol 2018. doi: 10.1038/s41571-018-0046-7

10-05-2018 | Non-small-cell lung cancer | Article

Safety of Programmed Death–1 Pathway Inhibitors Among Patients With Non–Small-Cell Lung Cancer and Preexisting Autoimmune Disorders

Leonardi GC et al. J Clin Oncol 2018; 36(19): 1905-1912. doi:10.1200/JCO.2017.77.0305

16-04-2018 | Lung cancer | Article

Neoadjuvant PD-1 Blockade in Resectable Lung Cancer

Forde PA et al. N Eng J Med 2018. doi:10.1056/NEJMoa1716078

16-04-2018 | Non-small-cell lung cancer | Article

Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden

Hellmann MD et al. N Eng J Med 2018. 10.1056/NEJMoa1801946

16-04-2018 | Pembrolizumab | Article

Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer

Gandhi L et al. N Eng J Med 2018. 10.1056/NEJMoa1801005

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