Skip to main content
Top

01-04-2016 | Gynecologic cancers | Article

12. Managing Cervical Cancer During Pregnancy

Publisher: Springer International Publishing

Abstract

Cervical cancer is one of the four most common malignancies in pregnancy. The coincidence of cancer diagnosed in pregnancy generally increases. Because pregnancy itself does not negatively influence the prognosis of cervical cancer patients, pregnancy-preserving management should be considered as majority of cases are diagnosed at the early stage of disease. Pelvic lymphadenectomy as a staging procedure can be safely performed until the 22nd gestational week. Abdominal or vaginal radical trachelectomy during pregnancy poses unacceptable risk to mother and foetus and therefore this procedure is not recommended. Neoadjuvant chemotherapy represents one of the most applicable treatment options in pregnancy-preserving management. Treatment decision must be done within an experienced, multidisciplinary team.
Literature
1.
Manuel-limson GA, Ladines-Llave CA, Sotto LS, Manalo AM. Cancer of the cervix in pregnancy: a 31-year experience at the Philippine General Hospital. J Obstet Gynaecol Res. 1997;23(6):503–9.CrossRefPubMed
2.
Sood AK, Sorosky JI, Krogman S, Anderson B, Benda J, Buller RE. Surgical management of cervical cancer complicating pregnancy: a case-control study. Gynecol Oncol. 1996;63(3):294–8.CrossRefPubMed
3.
Robova H, Rob L, Pluta M, Kacirek J, Halaska Jr M, Strnad P, et al. Squamous intraepithelial lesion-microinvasive carcinoma of the cervix during pregnancy. Eur J Gynaecol Oncol. 2005;26(6):611–4.PubMed
4.
Economos K, Perez VN, Delke I, Collado ML, Tancer ML. Abnormal cervical cytology in pregnancy: a 17-year experience. Obstet Gynecol. 1993;81(6):915–8.PubMed
5.
Balleyguier C, Fournet C, Ben HW, Zareski E, Morice P, Haie-Meder C, et al. Management of cervical cancer detected during pregnancy: role of magnetic resonance imaging. Clin Imaging. 2013;37(1):70–6.CrossRefPubMed
6.
Okuda Y, Sagami F, Tirone P, Morisetti A, Bussi S, Masters RE. [Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155) (3)-Study of embryo-fetal toxicity in rabbits by intravenous administration]. J Toxicol Sci. 1999;24 Suppl 1:79–7.
7.
Vercellino GF, Koehler C, Erdemoglu E, Mangler M, Lanowska M, Malak AH, et al. Laparoscopic pelvic lymphadenectomy in 32 pregnant patients with cervical cancer: rationale, description of the technique, and outcome. Int J Gynecol Cancer. 2014;24(2):364–71.CrossRefPubMed
8.
Stan C, Megevand E, Irion O, Wang C, Bruchim I, Petignat P. Cervical cancer in pregnant women: laparoscopic evaluation before delaying treatment. Eur J Gynaecol Oncol. 2005;26(6):649–50.PubMed
9.
Alouini S, Rida K, Mathevet P. Cervical cancer complicating pregnancy: implications of laparoscopic lymphadenectomy. Gynecol Oncol. 2008;108(3):472–7.CrossRefPubMed
10.
Sioutas A, Schedvins K, Larson B, Gemzell-Danielsson K. Three cases of vaginal radical trachelectomy during pregnancy. Gynecol Oncol. 2011;121(2):420–1.CrossRefPubMed
11.
Ferraioli D, Buenerd A, Marchiole P, Constantini S, Venturini PL, Mathevet P. Early invasive cervical cancer during pregnancy: different therapeutic options to preserve fertility. Int J Gynecol Cancer. 2012;22(5):842–9.CrossRefPubMed
12.
Carillon MA, Emmanuelli V, Castelain B, Taieb S, Collinet P, Vinatier D, et al. [Management of pregnant women with advanced cervical cancer: about five cases observed in Lille from 2002 till 2009. Evaluation of practices referring to the new French recommendations of 2008]. J Gynecol Obstet Biol Reprod (Paris). 2011;40(6):514–21.CrossRef
13.
Rob L, Skapa P, Robova H. Fertility-sparing surgery in patients with cervical cancer. Lancet Oncol. 2011;12(2):192–200.CrossRefPubMed
14.
Ben-Arie A, Levy R, Lavie O, Edwards C, Kaplan A. Conservative treatment of stage IA2 squamous cell carcinoma of the cervix during pregnancy. Obstet Gynecol. 2004;104(5 Pt 2):1129–31.CrossRefPubMed
15.
van Calsteren K, Hanssens M, Moerman P, Orye G, Bielen D, Vergote I, et al. Successful conservative treatment of endocervical adenocarcinoma stage Ib1 diagnosed early in pregnancy. Acta Obstet Gynecol Scand. 2008;87(2):250–3.CrossRefPubMed
16.
Morice P, Uzan C, Gouy S, Verschraegen C, Haie-Meder C. Gynaecological cancers in pregnancy. Lancet. 2012;379(9815):558–69.CrossRefPubMed
17.
Ungar L, Smith JR, Palfalvi L, Del PG. Abdominal radical trachelectomy during pregnancy to preserve pregnancy and fertility. Obstet Gynecol. 2006;108(3 Pt 2):811–4.CrossRefPubMed
18.
Mandic A, Novakovic P, Nincic D, Zivaljevic M, Rajovic J. Radical abdominal trachelectomy in the 19th gestation week in patients with early invasive cervical carcinoma: case study and overview of literature. Am J Obstet Gynecol. 2009;201(2):e6–8.CrossRefPubMed
19.
Abu-Rustum NR, Tal MN, DeLair D, Shih K, Sonoda Y. Radical abdominal trachelectomy for stage IB1 cervical cancer at 15-week gestation. Gynecol Oncol. 2010;116(1):151–2.CrossRefPubMed
20.
Enomoto T, Yoshino K, Fujita M, Miyoshi Y, Ueda Y, Koyama S, et al. A successful case of abdominal radical trachelectomy for cervical cancer during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2011;158(2):365–6.CrossRefPubMed
21.
Aoki Y, Inamine M, Ohishi S, Nagai Y, Masamoto H. Radical abdominal trachelectomy for IB1 cervical cancer at 17 weeks of gestation: a case report and literature review. Case Rep Obstet Gynecol. 2014;2014:926502.PubMedPubMedCentral
22.
Karateke A, Cam C, Celik C, Baykal B, Tug N, Ozbasli E, et al. Radical trachelectomy in late pregnancy: is it an option? Eur J Obstet Gynecol Reprod Biol. 2010;152(1):112–3.CrossRefPubMed
23.
Bravo E, Parry S, Alonso C, Rojas S. Radical vaginal trachelectomy and laparoscopic pelvic lymphadenectomy in IB1 cervical cancer during pregnancy. Gynecol Oncol Case Rep. 2012;2(3):78–9.CrossRefPubMedPubMedCentral
24.
Iwami N, Ishioka S, Endo T, Baba T, Nagasawa K, Takahashi M, et al. First case of vaginal radical trachelectomy in a pregnant Japanese woman. Int J Clin Oncol. 2011;16(6):737–40.CrossRefPubMed
25.
Kolomainen DF, Bradley RJ, Larsen-Disney P, Shepherd JH. Radical vaginal trachelectomy at 16 weeks’ gestation: a case report. Gynecol Oncol Case Rep. 2013;5:28–30.CrossRefPubMedPubMedCentral
26.
van de Nieuwenhof HP, van Ham MA, Lotgering FK, Massuger LF. First case of vaginal radical trachelectomy in a pregnant patient. Int J Gynecol Cancer. 2008;18(6):1381–5.CrossRefPubMed
27.
Saso S, Sawyer R, O’Neill NM, Tzafetas M, Sayasneh A, Hassan HA, et al. Trachelectomy during pregnancy: what has experience taught us? J Obstet Gynaecol Res. 2015;41(4):640–5.CrossRefPubMed
28.
Cardonick E, Usmani A, Ghaffar S. Perinatal outcomes of a pregnancy complicated by cancer, including neonatal follow-up after in utero exposure to chemotherapy: results of an international registry. Am J Clin Oncol. 2010;33(3):221–8.PubMed
29.
Favero G, Chiantera V, Oleszczuk A, Gallotta V, Hertel H, Herrmann J, et al. Invasive cervical cancer during pregnancy: laparoscopic nodal evaluation before oncologic treatment delay. Gynecol Oncol. 2010;118(2):123–7.CrossRefPubMed
30.
Marnitz S, Kohler C, Oppelt P, Schmittel A, Favero G, Hasenbein K, et al. Cisplatin application in pregnancy: first in vivo analysis of 7 patients. Oncology. 2010;79(1-2):72–7.CrossRefPubMed
31.
Giacalone PL, Laffargue F, Benos P, Rousseau O, Hedon B. Cis-platinum neoadjuvant chemotherapy in a pregnant woman with invasive carcinoma of the uterine cervix. Br J Obstet Gynaecol. 1996;103(9):932–4.CrossRefPubMed
32.
Fruscio R, Villa A, Chiari S, Vergani P, Ceppi L, Dell’Orto F, et al. Delivery delay with neoadjuvant chemotherapy for cervical cancer patients during pregnancy: a series of nine cases and literature review. Gynecol Oncol. 2012;126(2):192–7.CrossRefPubMed
33.
Ayhan A, Dursun P, Karakaya BK, Ozen O, Tarhan C. Neoadjuvant chemotherapy followed by cesarean radical hysterectomy in a triplet pregnancy complicated by clear cell carcinoma of the cervix: a case presentation and literature review. Int J Gynecol Cancer. 2012;22(7):1198–202.CrossRefPubMed
34.
Caluwaerts S, Van CK, Mertens L, Lagae L, Moerman P, Hanssens M, et al. Neoadjuvant chemotherapy followed by radical hysterectomy for invasive cervical cancer diagnosed during pregnancy: report of a case and review of the literature. Int J Gynecol Cancer. 2006;16(2):905–8.CrossRefPubMed
35.
Chun KC, Kim DY, Kim JH, Kim YM, Kim YT, Nam JH. Neoadjuvant chemotherapy with paclitaxel plus platinum followed by radical surgery in early cervical cancer during pregnancy: three case reports. Jpn J Clin Oncol. 2010;40(7):694–8.CrossRefPubMed
36.
de Lima CA, Barcelos AC, Paschoini MC, Silva JH, de Lima MA, Murta EF, et al. Conservative treatment of uterine cervical adenocarcinoma in pregnancy. Case Rep Obstet Gynecol. 2013;2013:692017.PubMedPubMedCentral
37.
Kong TW, Lee EJ, Lee Y, Chang SJ, Son JH, Ryu HS. Neoadjuvant and postoperative chemotherapy with paclitaxel plus cisplatin for the treatment of FIGO stage IB cervical cancer in pregnancy. Obstet Gynecol Sci. 2014;57(6):539–43.CrossRefPubMedPubMedCentral
38.
Karam A, Feldman N, Holschneider CH. Neoadjuvant cisplatin and radical cesarean hysterectomy for cervical cancer in pregnancy. Nat Clin Pract Oncol. 2007;4(6):375–80.CrossRefPubMed
39.
Li J, Wang LJ, Zhang BZ, Peng YP, Lin ZQ. Neoadjuvant chemotherapy with paclitaxel plus platinum for invasive cervical cancer in pregnancy: two case report and literature review. Arch Gynecol Obstet. 2011;284(3):779–83.CrossRefPubMed
40.
Peculis LD, Ius Y, Campion M, Friedlander M, Hacker N. Stage IB2 adenosquamous cervical cancer diagnosed at 19-weeks gestation. Aust N Z J Obstet Gynaecol. 2015;55(1):94–7.CrossRefPubMed
41.
Rabaiotti E, Sigismondi C, Montoli S, Mangili G, Candiani M, Vigano R. Management of locally advanced cervical cancer in pregnancy: a case report. Tumori. 2010;96(4):623–6.PubMed
42.
Islam S, Mukhopadhyay L, Howells R. Neo-adjuvant chemotherapy and radical surgery for stage 1B cervical cancer in pregnancy. J Obstet Gynaecol. 2012;32(2):191–2.CrossRefPubMed
43.
Tewari K, Cappuccini F, Gambino A, Kohler MF, Pecorelli S, Disaia PJ. Neoadjuvant chemotherapy in the treatment of locally advanced cervical carcinoma in pregnancy: a report of two cases and review of issues specific to the management of cervical carcinoma in pregnancy including planned delay of therapy. Cancer. 1998;82(8):1529–34.CrossRefPubMed
44.
Smyth EC, Korpanty G, McCaffrey JA, Mulligan N, Carney DN. Small-cell carcinoma of the cervix at 23 weeks gestation. J Clin Oncol. 2010;28(18):e295–7.CrossRefPubMed
45.
Lai CH, Hsueh S, Chang TC, Tseng CJ, Huang KG, Chou HH, et al. Prognostic factors in patients with bulky stage IB or IIA cervical carcinoma undergoing neoadjuvant chemotherapy and radical hysterectomy. Gynecol Oncol. 1997;64(3):456–62.CrossRefPubMed
46.
Lanowska M, Kohler C, Oppelt P, Schmittel A, Gottschalk E, Hasenbein K, et al. Addressing concerns about cisplatin application during pregnancy. J Perinat Med. 2011;39(3):279–85.CrossRefPubMed
47.
Gambino A, Gorio A, Carrara L, Agoni L, Franzini R, Lupi GP, et al. Cancer in pregnancy: maternal and fetal implications on decision-making. Eur J Gynaecol Oncol. 2011;32(1):40–5.PubMed
48.
Amant F, Halaska MJ, Fumagalli M, Dahl SK, Lok C, Van CK, et al. Gynecologic cancers in pregnancy: guidelines of a second international consensus meeting. Int J Gynecol Cancer. 2014;24(3):394–403.CrossRefPubMed
49.
Goldman NA, Goldberg GL. Late recurrence of squamous cell cervical cancer in an episiotomy site after vaginal delivery. Obstet Gynecol. 2003;101(5 Pt 2):1127–9.PubMed