Cervical cancer is an important cause of morbidity and mortality worldwide, with significant disparities between low- and high-resource settings. Effective preventive measures exist for this devastating disease, including Pap screening and HPV vaccination; however, access to care remains an important barrier. The ED, which is an important safety net for underserved populations, could serve as a site for education and screening for HPV. ED visits are a missed opportunity for preventive health measures including cervical cancer prevention and detection. The potential for HPV vaccination in the ED remains to be seen, given that the focus of ED visits has not been on preventive care for this disease.