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16-02-2017 | Image

Figure 3: Therapeutic induction of cell death through targeting of the mitochondrial apoptosis pathway.

Proteins in the BCL-2 family are classified into pro-survival (orange colour) and pro-apoptotic groups. The pro-apoptotic proteins are further sub-divided into BCL-2 homology 3 (BH3)-only proteins (green colour) and effector proteins (blue colour).

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