27-09-2017 | Image
Synthetic lethal interactions may be dependent on certain intrinsic conditions such as genetic background, hypoxia or metabolic changes (part Aa), or extrinsic conditions such as treatment with DNA-damaging agents, which results in synthetic cytotoxicity (part Ab). Conversely, synthetic lethal interactions may be suppressed by conditions such as genetic background mutations (part B). The star shape denotes a mutation. The red crosses denote pharmacological inhibition. The lightning bolt denotes DNA damage. Viable cells are depicted as ovals, and inviable cells are depicted as random shapes. ROS, reactive oxygen species; SLP, synthetic lethal partner.