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21-04-2020 | FDA | News

approvalsWatch

Tucatinib combination approved for advanced HER2-positive breast cancer

Author:
Lynda Williams

medwireNews: The US FDA has approved the use of tucatinib as a second-line or later treatment for patients with advanced unresectable or metastatic HER2-positive breast cancer.

The oral small molecule inhibitor of HER2 may be used alongside trastuzumab and capecitabine after initial use of one or more anti-HER2-based regimens.

The decision is based on results of the HER2CLIMB trial which demonstrated a progression-free survival benefit with the addition of tucatinib to trastuzumab and capecitabine after prior treatment with trastuzumab, pertuzumab, or ado-trastuzumab emtansine, including among patients with brain metastases.

The recommended tucatinib dose is 300 mg twice daily and common adverse events reported include diarrhea, palmar–plantar erythrodysesthesia, nausea, fatigue, and hepatotoxicity.

medwireNews is an independent medical news service provided by Springer Healthcare. © 2020 Springer Healthcare part of the Springer Nature Group

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