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Hematologic cancers: Screening, diagnosis and staging

Journal articles and book chapters

04-04-2018 | Myelodysplastic syndrome | Article

Incorporation of mutations in five genes in the revised International Prognostic Scoring System can improve risk stratification in the patients with myelodysplastic syndrome

Hou H-A et al. Blood Cancer J 2018; 8: 39. doi:10.1038/s41408-018-0074-7

27-02-2018 | Leukemia | Article

Universal genetic testing for inherited susceptibility in children and adults with myelodysplastic syndrome and acute myeloid leukemia: are we there yet?

Tawana K et al. Leukemia 2018. doi:10.1038/s41375-018-0051-y

20-02-2018 | Follicular lymphoma | Article

A gene-expression profiling score for prediction of outcome in patients with follicular lymphoma: a retrospective training and validation analysis in three international cohorts

Huet S et al. N Eng J Med 2018; 19(4): 549-561. doi:10.1016/S1470-2045(18)30102-5

12-01-2018 | Leukemia | Article

De novo pure erythroid leukemia: refining the clinicopathologic and cytogenetic characteristics of a rare entity

Reinig E et al. Mod Pathol 2018; doi:10.1038/modpathol.2017.175

10-01-2018 | Acute myeloid leukemia | Article

Mutations in DNMT3A, U2AF1, and EZH2 identify intermediate-risk acute myeloid leukemia patients with poor outcome after CR1

Saygin C et al. Blood Cancer J 2018; doi:10.1038/s41408-017-0040-9

19-12-2017 | Pediatric leukemia | Article

Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia

Stieglitz E et al. Nat Commun 2017; doi:10.1038/s41467-017-02178-9

18-12-2017 | Acute myeloid leukemia | Article

Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia

Rothenberg-Thurley M et al. Leukemia 2017; doi:10.1038/leu.2017.350

18-12-2017 | Acute myeloid leukemia | Article

Chromothripsis in acute myeloid leukemia: Biological features and impact on survival

Fontana M et al. Leukemia 2017; doi:10.1038/leu.2017.351

18-12-2017 | Acute lymphoblastic leukemia | Article

Flow cytometric vs morphologic assessment of remission in childhood acute lymphoblastic leukemia: A report from the Children’s Oncology Group (COG)

Gupta S et al. Leukemia 2017; doi:10.1038/leu.2017.341

11-12-2017 | Acute myeloid leukemia | Article

The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

Bolouri H et al. Nat Med 2017; doi:10.1038/nm.4439

28-11-2017 | Leukemia | Article

Combining cytogenetic and epigenetic approaches in chronic lymphocytic leukemia improves prognosis prediction for patients with isolated 13q deletion

Bagacean C, Le Dantec C, Berthou C et al. Clin Epigenet 2017; 9:122. doi:10.1186/s13148-017-0422-7

27-11-2017 | Leukemia | Article

Minimal residual disease by either flow cytometry or cytogenetics prior to an allogeneic hematopoietic stem cell transplant is associated with poor outcome in acute myeloid leukemia

Blood Cancer J 2017; 7(12)634. doi:10.1038/s41408-017-0007-x

24-10-2017 | Acute myeloid leukemia | Article

Measurement of residual disease in acute myeloid leukemia

Vedula RS & Lindsley RC. Curr Hematol Malig Rep 2017. doi:10.1007/s11899-017-0428-4

24-10-2017 | Acute myeloid leukemia | Article

Diagnostic and prognostic utility of fluorescence in situ hybridization (FISH) analysis in acute myeloid leukemia

The authors review the use of several fluorescence in situ hybridization probe strategies in the diagnosis of acute myeloid leukemia (AML), together with current clinical guidelines for AML diagnosis.

Gonzales PR & Mikhail FM. Curr Hematol Malig Rep 2017. doi:10.1007/s11899-017-0426-6

13-10-2017 | Acute myeloid leukemia | Article

The prognostic significance of measurable (“minimal”) residual disease in acute myeloid leukemia

In this review, Buccisano et al evaluate recent literature on detection methodologies for, and prognostic significance of, measurable residual disease in acute myeloid leukemia.

Buccisano F, Hourigan CS & Walter RB Curr Hematol Malig Rep 2017. doi:10.1007/s11899-017-0420-z

13-09-2017 | Pediatric leukemia | Article

Genetic susceptibility in childhood acute lymphoblastic leukemia

The authors review the most important findings regarding genetic susceptibility to childhood acute lymphoblastic leukemia (ALL), specifically the major subtype B-cell precursor ALL, and point to new findings with important implications.

Gutierrez-Camino A et al. Med Oncol 2017; 34: 179. doi:10.1007/s12032-017-1038-7

31-07-2017 | Leukemia | Article

Targeted next-generation sequencing identifies clinically relevant mutations in patients with chronic neutrophilic leukemia at diagnosis and blast crisis

Next-generation sequencing is shown to be able to identify clinically relevant myeloid malignancy-associated mutations when applied to a case series of patients with chronic neutrophilic leukemia.

Langabeer SE et al. Clin Transl Oncol 2017. doi:10.1007/s12094-017-1722-2

03-07-2017 | Pediatric leukemia | Article

The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia

This article reports an integrated genomic analysis of young subjects with T-lineage acute lymphoblastic leukemia that identifies previously unrecognized mutation targets and modalities of mutation.

Nat Gen 2017; 49: 1211–1218. doi:10.1038/ng.3909

22-05-2017 | Lymphoma | Article

Imaging children suffering from lymphoma: an evaluation of different 18F-FDG PET/MRI protocols compared to whole-body DW-MRI

Kirchner J, Deuschl C, Schweiger B et al. Eur J Nucl Med Mol Imaging 2017; 44: 1742-1750. doi:10.1007/s00259-017-3726-0

24-02-2017 | Liquid biopsy | Review | Article

Liquid biopsies come of age: Towards implementation of circulating tumor DNA

Nat Rev Cancer 2017; 17: 223–238. doi: 10.1038/nrc.2017.7

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