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17-05-2018 | Breast cancer | Article

Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers

Journal:
Breast Cancer Research and Treatment

Authors: Joanne Kotsopoulos, Jacek Gronwald, Henry T. Lynch, Andrea Eisen, Susan L. Neuhausen, Nadine Tung, Peter Ainsworth, Jeffrey N. Weitzel, Tuya Pal, William D. Foulkes, Charis Eng, Christian F. Singer, Leigha Senter, Ping Sun, Jan Lubinski, Steven A. Narod, the Hereditary Breast Cancer Clinical Study Group

Publisher: Springer US

Abstract

Purpose

In the general population, an early age at first full-term birth confers protection against the risk of developing breast cancer. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Thus, we undertook a case–control study of women with a BRCA1 or BRCA2 mutation to study the effects of age at first full-term birth matched for other reproductive factors.

Methods

Information about reproductive factors, including age at first birth as well as medical history, was collected from a routinely administered research questionnaire. There were 2,295 matched pairs of women with a BRCA1 or BRCA2 mutation included in the final analysis.

Results

There was no significant difference in the mean age at first full-term birth among the BRCA1 (24.9 vs. 25.2; P = 0.10) or BRCA2 mutation carriers (26.5 vs. 26.6 years; P = 0.80). Findings were similar in the analysis limited to cases who were diagnosed with breast cancer prior to age 45.

Conclusion

This matched analysis of a large number of BRCA mutation carriers suggests that age at first birth has little influence on BRCA1 or BRCA2 breast cancer risk.

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