15-04-2018 | Breast cancer | Article
Immunotherapy in Breast Cancer: the New Frontier
Journal: Current Breast Cancer Reports
Authors: Zishuo I. Hu, Heather L. McArthur
Publisher: Springer US
Abstract
Purpose of review
This review summarizes current immunotherapies in breast cancer, with an emphasis on immune checkpoint inhibitors and vaccines.
Recent findings
Combination immunotherapy with checkpoint inhibitors and cytotoxic therapies have shown promising results. Active clinical trials are ongoing in both early stage and metastatic settings for triple negative, HER2+, and hormone-positive breast cancer patients.
Summary
Ongoing challenges remain in defining biomarkers that predict response to immunotherapy, determining the optimal combination immunotherapies, and enhancing the immunogenicity of breast cancer subtypes.