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Breast cancer

News and opinion

13-12-2018 | HER2-positive breast cancer | News

Adjuvant trastuzumab emtansine reduces HER2-positive breast cancer recurrence risk

Among patients with early-stage HER2-positive breast cancer who have residual disease after neoadjuvant therapy and surgery, the use of trastuzumab emtansine instead of trastuzumab leads to significant improvements in invasive disease-free survival, indicate KATHERINE trial findings.

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N Engl J Med 2018; doi:10.1056/NEJMoa1814017
SABCS 2018; San Antonio, Texas, USA; 4–8 December

03-12-2018 | FDA | Drug approval | News

approvalsWatch

Positive FDA decisions for lorlatinib, talazoparib, pembrolizumab

Read more about these approvals here

19-11-2018 | Head and neck cancers | ESMO 2018 | Video

Experts reflect on their highlights from ESMO 2018

Hisham Mehanna, Ricardo Alvarez and Massimo Christofanilli, and Thomas Seufferlein discuss their ESMO 2018 highlights in head & neck, breast, and gastrointestinal cancer, respectively (7:42).

06-11-2018 | Breast cancer | News

NCRI 2018

Early risers may have reduced breast cancer risk

Women who function better earlier in the day, so-called morning people, are less likely to develop breast cancer than those who consider themselves night owls, suggests a Mendelian randomization analysis.

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NCRI 2018; Glasgow, UK; 4–6 November

06-11-2018 | Chemoprevention | News

NCRI 2018

Run-in period may improve adherence to aspirin for chemoprevention

In patients undergoing radical therapy for cancer, an 8-week run-in period of aspirin is acceptable and well tolerated, and could reduce the risk for nonadherence and participant attrition in adjuvant and prevention trials, say researchers.

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NCRI 2018; Glasgow, UK

05-11-2018 | Breast cancer | ESMO 2018 | News

Epigenetic therapy shows promise for HR-positive advanced breast cancer

Supplementing exemestane with the selective histone deacetylase inhibitor chidamide significantly prolongs the progression-free survival of women with hormone receptor-positive, HER2-negative advanced breast cancer, phase III trial findings indicate.

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ESMO 2018; Munich, Germany; 19–23 October

28-10-2018 | Breast cancer | ESMO 2018 | Video

Tumor-infiltrating lymphocytes show prognostic potential in HER2-positive breast cancer

Maria Vittoria Dieci describes the ShortHER trial’s findings on tumor-infiltrating lymphocytes and their prognostic value in patients undergoing treatment for early HER2-positive breast cancer (6:03).

24-10-2018 | Tamoxifen | ESMO 2018 | Video

Serum analysis sheds light on tamoxifen adherence

Barbara Pistilli discusses the CANTO COMPLETE study of premenopausal breast cancer patient adherence to endocrine therapy (4:31).

24-10-2018 | Breast cancer | ESMO 2018 | Video

Evaluating alpelisib addition to standard of care in SOLAR-1

We speak to Fabrice André about the SOLAR-1 trial and its impact on the care of patients with hormone receptor-positive, HER2-negative advanced breast cancer (5:19).

23-10-2018 | Breast cancer | ESMO 2018 | News

News in brief

Serum testing reveals tamoxifen therapy nonadherence

Serum analysis suggests that within a year of beginning endocrine therapy after early breast cancer treatment, around one in six premenopausal women are no longer adherent to tamoxifen.

21-10-2018 | Triple-negative breast cancer | ESMO 2018 | News

IMpassion130 supports atezolizumab use in triple-negative breast cancer

Results for the IMpassion130 trial support the combination of atezolizumab and nab-paclitaxel for the treatment of metastatic triple-negative breast cancer, especially among patients with programmed cell death ligand 1-positive disease.

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N Engl J Med 2018; doi:10.1056/NEJMoa1809615
ESMO 2018; Munich, Germany: 18–23 October

21-10-2018 | Breast cancer | ESMO 2018 | News

Adding alpelisib to fulvestrant boosts PI3KCA-mutant metastatic breast cancer PFS

Patients with hormone receptor-positive, HER2-negative metastatic breast cancer harboring PI3KCA mutations derive a significant progression-free survival benefit when fulvestrant is supplemented with the PI3K inhibitor alpelisib, phase III data show.

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ESMO 2018; Munich, Germany; 19–23 October

20-10-2018 | Breast cancer | ESMO 2018 | News

Further evidence for palbociclib addition in advanced breast cancer

PALOMA-3 trial findings show that overall survival is significantly improved with the addition of the CDK4/6 inhibitor palbociclib to fulvestrant in patients with hormone receptor-positive, HER2-negative advanced breast cancer and sensitivity to prior endocrine therapy.

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ESMO 2018; Munich, Germany; 19–23 October
N Engl J Med 2018; doi:10.1056/NEJMoa1810527

12-10-2018 | Breast cancer | News

Endocrine therapy impacts cardiovascular risk in women with breast cancer

Long-term use of adjuvant endocrine therapy by women with a history of nonmetastatic breast cancer can significantly alter their risk for some types of cardiovascular disease, a meta-analysis shows.

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BMJ 2018; 363: k3845

11-10-2018 | Breast cancer | News

News in brief

Postmenopausal weight loss linked to reduced breast cancer risk

Postmenopausal women who lose weight have a lower risk for breast cancer than those who maintain a stable weight, report researchers.

10-10-2018 | Chemotherapy | News

Short-term hospitalization, mortality risk varies by palliative chemotherapy regimen

Two independent studies of older patients receiving initial chemotherapy for metastatic breast cancer or non-small-cell lung cancer have found that the risk for hospitalization or death may be predicted by the cytotoxic regimen used.

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Cancer 2018; doi:10.1002/cncr.31760
JAMA Network Open 2018; 1: e183023

09-10-2018 | Breast cancer | News

Lurbinectedin activity shown in metastatic breast cancer

Lurbinectedin, a selective inhibitor of active transcription of protein-coding genes, has promising activity in patients with BRCA1/2-mutated metastatic breast cancer, phase II study data show.

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J Clin Oncol 2018; doi:10.1200/JCO.2018.78.6558

18-09-2018 | EMA | News

approvalsWatch

Durvalumab, abemaciclib approvals announced by EMA

Click through to read more

03-09-2018 | Advanced breast cancer | News

EMBRACA results demonstrate talazoparib advanced breast cancer benefits

The PARP inhibitor talazoparib extends progression-free survival and improves quality of life compared with standard chemotherapy, show findings from the phase III EMBRACA study of women with advanced breast cancer and a germline BRCA1/2 mutation.

Source:

N Engl J Med 2018; 379: 753–763
Ann Oncol 2018; doi:10.1093/annonc/mdy257

31-08-2018 | Breast cancer | News

In other news: Breast cancer treatment effects

The focus this month is on early and late treatment effects in patients with breast cancer, including effects on endometrial cancer risk, cardiotoxicity, and skin toxicity.

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