PACIFIC at 5 years shows ‘robust and sustained’ OS benefit with durvalumab
medwireNews: Five-year findings from the PACIFIC trial for patients with unresectable stage III non-small-cell lung cancer (NSCLC) continue to show survival benefits with 1 year of durvalumab therapy versus placebo after platinum-based chemoradiotherapy.
David Spigel (Sarah Cannon Research Institute, Nashville, Tennessee, USA) told delegates at the 2021 ASCO Annual Meeting that the PD-L1 inhibitor study update demonstrated “robust and sustained” overall survival (OS) and “durable” progression-free survival (PFS), following on from the initial OS and PFS benefits reported.
At data cutoff in January 2021, 55.5% of participants given durvalumab and 65.4% of placebo-treated patients had died. There was a significant OS benefit found for durvalumab, with a hazard ratio (HR) for death of 0.72.
PFS also significantly favored durvalumab use, with a HR of 0.55. In all, 33% of treated patients were alive and free from disease versus 19% of controls, and updated OS and PFS subgroup analyses “were consistent with the results reported at the time of the primary analysis,” the presenter said.
“This establishes a new benchmark for the standard of care in the unresectable stage III non-small-cell lung cancer setting,” Spigel concluded.
“The PACIFIC regimen is being investigated in combination with different chemoradiotherapy regimens as well as with other agents following chemoradiotherapy.”
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