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Acute myeloid leukemia

Journal articles and book chapters

27-02-2018 | Acute myeloid leukemia | Article

Successes and challenges in the treatment of pediatric acute myeloid leukemia: a retrospective analysis of the AML-BFM trials from 1987 to 2012

Rasche M et al. Leukemia 2018. doi:10.1038/s41375-018-0071-7

27-02-2018 | Leukemia | Article

Universal genetic testing for inherited susceptibility in children and adults with myelodysplastic syndrome and acute myeloid leukemia: are we there yet?

Tawana K et al. Leukemia 2018. doi:10.1038/s41375-018-0051-y

12-01-2018 | Acute myeloid leukemia | Article

Impact of antithymocyte globulin doses in reduced intensity conditioning before allogeneic transplantation from matched sibling donor for patients with acute myeloid leukemia: a report from the acute leukemia working party of European group of Bone Marrow Transplantation

Devillier R et al. Bone Marrow Transplant 2018; doi:10.1038/s41409-017-0043-y

10-01-2018 | Acute myeloid leukemia | Article

Mutations in DNMT3A, U2AF1, and EZH2 identify intermediate-risk acute myeloid leukemia patients with poor outcome after CR1

Saygin C et al. Blood Cancer J 2018; doi:10.1038/s41408-017-0040-9

18-12-2017 | Acute myeloid leukemia | Article

Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia

Rothenberg-Thurley M et al. Leukemia 2017; doi:10.1038/leu.2017.350

18-12-2017 | Acute myeloid leukemia | Article

Chromothripsis in acute myeloid leukemia: Biological features and impact on survival

Fontana M et al. Leukemia 2017; doi:10.1038/leu.2017.351

11-12-2017 | Acute myeloid leukemia | Article

The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

Bolouri H et al. Nat Med 2017; doi:10.1038/nm.4439

27-11-2017 | Leukemia | Article

Minimal residual disease by either flow cytometry or cytogenetics prior to an allogeneic hematopoietic stem cell transplant is associated with poor outcome in acute myeloid leukemia

Blood Cancer J 2017; 7(12)634. doi:10.1038/s41408-017-0007-x

23-11-2017 | Leukemia | Article

Levofloxacin for febrile neutropenia prophylaxis in acute myeloid leukemia patients associated with reduction in hospital admissions

Lee SSF, Fulford AE, Quinn MA, Seabrook J & Rajakumar I. Support Care Cancer 2017. doi:10.1007/s00520-017-3976-1

08-11-2017 | Leukemia | Article

Asparaginase Erwinia chrysanthemi effectively depletes plasma glutamine in adult patients with relapsed/refractory acute myeloid leukemia

Emadi A, Law JY, Strovel ET et al. Cancer Chemother Pharmacol 2018; 81(1):217  doi:10.1007/s00280-017-3459-6

31-10-2017 | Acute myeloid leukemia | Article

The role of mutant IDH1 and IDH2 inhibitors in the treatment of acute myeloid leukemia

This article summarizes the role of isocitrate dehydrogenase (IDH)-1 and IDH2 mutations in leukemogenesis, and covers recent clinical trials evaluating the effect of direct inhibition of IDH1 and IDH2.

Nassereddine S, Lap CJ, Haroun F et al. Ann Hematol 2017; 96:1983. doi:10.1007/s00277-017-3161-0

31-10-2017 | Acute myeloid leukemia | Article

Epidemiological, genetic, and clinical characterization by age of newly diagnosed acute myeloid leukemia based on an academic population-based registry study (AMLSG BiO)

Nagel G, Weber D, Fromm E et al. Ann Hematol 2017; 96:1993. doi:10.1007/s00277-017-3150-3

24-10-2017 | Acute myeloid leukemia | Article

Measurement of residual disease in acute myeloid leukemia

Vedula RS & Lindsley RC. Curr Hematol Malig Rep 2017. doi:10.1007/s11899-017-0428-4

24-10-2017 | Acute myeloid leukemia | Article

Diagnostic and prognostic utility of fluorescence in situ hybridization (FISH) analysis in acute myeloid leukemia

The authors review the use of several fluorescence in situ hybridization probe strategies in the diagnosis of acute myeloid leukemia (AML), together with current clinical guidelines for AML diagnosis.

Gonzales PR & Mikhail FM. Curr Hematol Malig Rep 2017. doi:10.1007/s11899-017-0426-6

13-10-2017 | Acute myeloid leukemia | Article

The prognostic significance of measurable (“minimal”) residual disease in acute myeloid leukemia

In this review, Buccisano et al evaluate recent literature on detection methodologies for, and prognostic significance of, measurable residual disease in acute myeloid leukemia.

Buccisano F, Hourigan CS & Walter RB Curr Hematol Malig Rep 2017. doi:10.1007/s11899-017-0420-z

25-07-2017 | Acute myeloid leukemia | Article

Recent developments in immunotherapy of acute myeloid leukemia

This review surveys the current most prominent concepts in the immunotherapy of acute myeloid leukemia as well as the considerable progress made over the past few years.

Lichtenegger FS et al. J Hematol Oncol 2017; 10: 142. doi:10.1186/s13045-017-0505-0

08-06-2017 | Acute myeloid leukemia | Article

Predictors of thrombohemorrhagic early death in children and adolescents with t(15;17)-positive acute promyelocytic leukemia treated with ATRA and chemotherapy

Abla O et al. Ann Hematol 2017; 96: 1449–1456. doi:10.1007/s00277-017-3042-6


15-11-2016 | Hematologic cancers | Book chapter | Article

Therapeutic management of acute myeloid leukemia

In this chapter Fiegl provides an overview of the treatment options for patients with acute myeloid leukemia by phase, with resistant/relapsed disease, and in those deemed medically unfit and elderly.

In: Handbook f Acute Leukemia. Edited by Hiddemann W. Springer International Publishing, 2016. doi:10.1007/978-3-319-26772-2_5

01-12-2015 | Hematologic cancers | Article

Molecular therapy for acute myeloid leukaemia

Coombs et al discuss the importance of integrating mutational data into treatment decisions for patients with acute myeloid leukemia and propose novel therapeutic algorithms in the era of molecular medicine.

Nat Rev Clin Oncol 2016; 13: 305–318. doi:10.1038/nrclinonc.2015.210

19-07-2018 | Acute myeloid leukemia | Article

Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML

DiNardo CD et al. N Engl J Med 2018; 378(25): 2386-2398. doi:10.1056/NEJMoa1716984