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15-11-2016 | Acute leukemia | Book chapter | Article

Diagnostic criteria, classification, and prognosis of acute leukemias

Klaus Metzeler
The currently accepted classification of acute leukemias was published in 2008 as part of the 4th edition of the World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues [1]. A revision has recently been published [2]. The aim of the WHO classification is to define distinct, non-overlapping, and reproducible entities based on clinical features, morphology, immunophenotype, and genetic information. It is important to note that the WHO system is aimed at assigning mutually exclusive diagnostic categories, and not primarily intended for risk stratification or treatment selection. Thus, additional classification systems are useful in clinical practice.

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